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Plos One : a Framework for Annotating Human Genome in Disease Context, Volume 7

By Bajic, Vladimir, B.

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Book Id: WPLBN0003932771
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : a Framework for Annotating Human Genome in Disease Context, Volume 7  
Author: Bajic, Vladimir, B.
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Historic
Publication Date:
Publisher: Plos

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Bajic, V. B. (n.d.). Plos One : a Framework for Annotating Human Genome in Disease Context, Volume 7. Retrieved from http://www.worldlibrary.in/


Description
Description : Identification of gene-disease association is crucial to understanding disease mechanism. A rapid increase in biomedical literatures, led by advances of genome-scale technologies, poses challenge for manually-curated-based annotation databases to characterize gene-disease associations effectively and timely. We propose an automatic method-The Disease Ontology Annotation Framework (DOAF) to provide a comprehensive annotation of the human genome using the computable Disease Ontology (DO), the NCBO Annotator service and NCBI Gene Reference Into Function (GeneRIF). DOAF can keep the resulting knowledgebase current by periodically executing automatic pipeline to re-annotate the human genome using the latest DO and GeneRIF releases at any frequency such as daily or monthly. Further, DOAF provides a computable and programmable environment which enables large-scale and integrative analysis by working with external analytic software or online service platforms. A user-friendly web interface (doa.nubic.northwestern.edu) is implemented to allow users to efficiently query, download, and view disease annotations and the underlying evidences.

 

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