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Oncogenes and Tumor-Suppressor Genes

By Lehman, Teresa A.

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Book Id: WPLBN0000122129
Format Type: PDF eBook
File Size: 0.9 MB
Reproduction Date: 2005

Title: Oncogenes and Tumor-Suppressor Genes  
Author: Lehman, Teresa A.
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Lehman, T. A. (n.d.). Oncogenes and Tumor-Suppressor Genes. Retrieved from

Government Reference Publication

Introduction: Carcinogenesis has long been thought to be due to an accumulation of genetic and epigenetic changes that cause abnormal regulation of molecular control of cell growth. The genetic changes can be the activation of proto-oncogenes and/or the inactivation of tumor-suppressor genes that can initiate tumorigenesis as well as enhance its progression. For example, Ki-ras activation in colorectal carcinoma is considered an early event (11, and gene amplification of N-mye has been associated with progression of human neuroblastoma (2). To date, only two tumor-suppressor genes have been well characterized. The retinohlastoma gene, Rb-I, has been found to be inactivated by mutation including deletions in retinoblastomas and other human tumors (3-5). The other tumor-suppressor gene recently identified is p53, which is mutated in colorectal, breast, brain, and lung carcinomas and may be involved in tumor progression (6,7).


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