World Library  
Flag as Inappropriate
Email this Article

Pumiliotoxin 251D

Article Id: WHEBN0013070931
Reproduction Date:

Title: Pumiliotoxin 251D  
Author: World Heritage Encyclopedia
Language: English
Subject: Phyllobates
Publisher: World Heritage Encyclopedia

Pumiliotoxin 251D

Pumiliotoxin 251D
CAS number 73376-35-9 N
PubChem 6440480
ChemSpider 4944741 N
ChEBI CHEBI:35596 YesY
Jmol-3D images Image 1
Molecular formula C16H29NO
Molar mass 251.41 g mol−1
Main hazards Toxic
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Pumiliotoxin 251D is one of the toxins found in the skin of poison frogs from the Dendrobates, Epipedobates, Minyobates and Phyllobates[1][2] and toads from the Melanophryniscus families.[3][4] It is not manufactured by the amphibians, but absorbed through their insect-rich diet.[5][6] It is extremely toxic to mosquitoes.[7]

Pumiliotoxin 251D is a powerful toxin with several mechanisms of action, both blocking sodium and potassium channels in cells,[8] and inhibiting calcium-dependent ATPase.[9][10]

Some poison frogs have the ability to convert pumiliotoxin 251D into allopumiliotoxin 267A, a more potent variant of the toxin.[11]


This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.