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Title: Pleuromutilin  
Author: World Heritage Encyclopedia
Language: English
Subject: ATC code J01, Peptidyl transferase
Publisher: World Heritage Encyclopedia


CAS number 125-65-5 YesY
PubChem 31326
Jmol-3D images Image 1
Molecular formula C22H34O5
Molar mass 378.502 g/mol
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Pleuromutilin and its derivatives are antibacterial drugs that inhibit protein synthesis in bacteria by binding to the peptidyl transferase component of the 50S subunit of ribosomes.[1][2]

This class of antibiotics includes azamulin and BC-3781.


Pleuromutilin was first discovered as an antibiotic in 1950.[3] It is derived from the fungus Clitopilus passeckerianus (formerly Pleurotus passeckerianus), and has also been found in Drosophila subatrata, Clitopilus scyphoides, and some other Clitopilus species.[4]


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