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Osler's nodes are painful, red, raised lesions found on the hands and feet. They are associated with a number of conditions, including infective endocarditis, and are caused by immune complex deposition. They are named after Sir William Osler who described them in the early 20th century.[1][2] Their presence is one definition of Osler's sign.[3]
Osler's nodes result from the deposition of immune complexes.[4] The resulting inflammatory response leads to swelling, redness, and pain that characterize these lesions.
The nodes are commonly indicative of subacute bacterial endocarditis.[5] 10–25% of endocarditis patients will have Osler's nodes. Other signs of endocarditis include Roth's spots and Janeway lesions. The latter, which also occur on the palms and soles, can be differentiated from Osler's nodes because they are nontender.[4]
It can also be seen in
Lymphatic system, Blood, Heart, Oxygen, Aorta
Complement system, Antibody, Hypersensitivity, Immunology, Antigen
Circulatory system, Osler's node, Icd-10, Endocarditis, Necrosis
Physical examination, Medicine, Pathology, Medical imaging, Respiratory examination
EMedicine, International Statistical Classification of Diseases and Related Health Problems, Icd-10, Medical Subject Headings, Type III hypersensitivity
Circulatory system, Aortic insufficiency, Austin Flint murmur, Caput medusae, Femoral artery
Circulatory system, Aortic insufficiency, Medical sign, Blood pressure, Austin Flint murmur