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Ghon's complex

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Title: Ghon's complex  
Author: World Heritage Encyclopedia
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Subject: Tuberculosis, Ghon focus, Cutaneous actinomycosis, Group JK corynebacterium sepsis, Histoid leprosy
Collection: Gross Pathology, Lung Disorders, Tuberculosis
Publisher: World Heritage Encyclopedia

Ghon's complex

Ghon's complex is a lesion seen in the lung that is caused by tuberculosis.[1][2] The lesions consist of a calcified focus of infection and an associated lymph node. These lesions are particularly common in children and can retain viable bacteria, so are sources of long-term infection and may be involved in reactivation of the disease in later life.[3]

In countries where cow milk infected with Mycobacterium bovis has been eliminated (due to culling of infected cows and pasteurization), primary tuberculosis is usually caused by Mycobacterium tuberculosis and almost always begins in the lungs. Typically, the inhaled bacilli implant in the distal airspaces of the lower part of the upper lobe or the upper part of the lower lobe, usually close to the pleura. As sensitization develops, a 1- to 1.5-cm area of gray-white inflammation with consolidation emerges, known as the Ghon focus. In most cases, the center of this focus undergoes caseous necrosis. Tubercle bacilli, either free or within phagocytes, drain to the regional nodes, which also often caseate. This combination of parenchymal lung lesion and nodal involvement is referred to as the Ghon complex. During the first few weeks there is also lymphatic and hematogenous dissemination to other parts of the body.

In approximately 95% of cases, development of cell-mediated immunity controls the infection.


The Ghon complex undergoes progressive

  1. ^ Ghon's primary lesion, Accessed 21 January 2008
  2. ^ Ober WB (1983). "Ghon but not forgotten: Anton Ghon and his complex". Pathol Annu. 18 Pt 2: 79–85.  
  3. ^ Curvo-Semedo L, Teixeira L, Caseiro-Alves F (2005). "Tuberculosis of the chest". Eur J Radiol 55 (2): 158–72.  
  4. ^ Robbins and Cotran pathologic basis of disease. – 8th ed. / Vinay Kumar…[et al.] 2010.
  5. ^ Robbins and Cotran pathologic basis of disease. – 8th ed. / Anand Athwal…[et al.] 2010.


See also


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