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Title: Citrinin  
Author: World Heritage Encyclopedia
Language: English
Subject: Mycotoxin, List of MeSH codes (D03), Mycotoxicology, Penicillium, Penicillium gorlenkoanum
Publisher: World Heritage Encyclopedia


CAS number  YesY
ChemSpider  N
Jmol-3D images Image 1
Molecular formula C13H14O5
Molar mass 250.25 g mol−1
Appearance Lemon-yellow needles
Melting point 175 °C (347 °F; 448 K) (decomposes)
Solubility in water Insoluble
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N   YesY/N?)

Citrinin is a mycotoxin originally isolated in 1931 by Hetherington and Raistrick from a culture of Penicillium citrinum.[2] It has since been found to be produced by a variety of other fungi that are found or used in the production of human foods, such as grain, cheese, sake, and red pigments. Citrinin has also been found in commercial red yeast rice supplements.[3]


Citrinin acts as a nephrotoxin in all species in which it has been tested, but its acute toxicity varies.[4] It causes mycotoxic nephropathy in livestock and has been implicated as a cause of Balkan nephropathy and yellow rice fever in humans.

Citrinin is used as a reagent in biological research. It induces mitochondrial permeability pore opening and inhibits respiration by interfering with complex III of the respiratory chain.

Citrinin can permeate through the human skin.[5] Although no significant health risk is expected after dermal contact in agricultural or residential environments, dermal exposure should nevertheless be limited.

Citrinin producers

Citrinin is produced by a variety of fungi, including:


  1. ^ Merck Index, 11th Edition, 2329.
  2. ^ Hetherington, A. C.; Raistrick, H. (1931). "On the Production and Chemical Constitution of a New Yellow Colouring Matter, Citrinin, Produced from Glucose by Penicillium citrinum Thom". Philosophical Transactions of the Royal Society B: Biological Sciences 220 (468–473): 269–95.  
  3. ^ Gordon, R. Y.; Cooperman, T.; Obermeyer, W.; Becker, D. J. (2010). "Marked Variability of Monacolin Levels in Commercial Red Yeast Rice Products: Buyer Beware!". Archives of Internal Medicine 170 (19): 1722–7.  
  4. ^ Bennett, J. W.; Klich, M. (2003). "Mycotoxins". Clinical Microbiology Reviews 16 (3): 497–516.  
  5. ^ Boonen, J.; Malysheva, S. V.; Taevernier, L.; Diana di Mavungu, J.; de Saeger, S.; de Spiegeleer, B. (2012). "Human skin penetration of selected model mycotoxins". Toxicology 301 (1–3): 21–32.  
  6. ^ "Citrinin".  
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