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Osteomyelitis of the tibia of a young child. Numerous abscesses in the bone show as radiolucency.
Classification and external resources
Specialty Infectious disease, orthopedics
ICD-10 M86
ICD-9-CM 730
DiseasesDB 9367
MedlinePlus 000437
eMedicine ped/1677
MeSH D010019

Osteomyelitis[1] (or OM) is pyogenic bacteria or mycobacteria) and the route, duration and anatomic location of the infection.


  • Classification 1
  • Cause 2
  • Pathogenesis 3
  • Diagnosis 4
  • Treatment 5
  • Fossil record 6
  • See also 7
  • Notes 8
  • References 9
  • Further reading 10
  • External links 11


The definition of OM is broad, and encompasses a wide variety of conditions. Traditionally, the length of time the infection has been present and whether there is suppuration (pus formation) or sclerosis (increased density of bone) is used to arbitrarily classify OM. Chronic OM is often defined as OM that has been present for more than one month. In reality, there are no distinct subtypes, instead there is a spectrum of pathologic features that reflect balance between the type and severity of the cause of the inflammation, the immune system and local and systemic predisposing factors.

  • Suppurative osteomyelitis
    • Acute suppurative osteomyelitis
    • Chronic suppurative osteomyelitis
      • Primary (no preceding phase)
      • Secondary (follows an acute phase)
  • Non-suppurative osteomyelitis

OM can also be typed according to the area of the skeleton in which it is present. For example, osteomyelitis of the jaws is different in several respects from osteomyelitis present in a long bone. Vertebral osteomyelitis is another possible presentation.


Age group Most common organisms
Newborns (younger than 4 mo) S. aureus, Enterobacter species, and group A and B Streptococcus species
Children (aged 4 mo to 4 y) S. aureus, group A Streptococcus species, Haemophilus influenzae, and Enterobacter species
Children, adolescents (aged 4 y to adult) S. aureus (80%), group A Streptococcus species, H. influenzae, and Enterobacter species
Adult S. aureus and occasionally Enterobacter or Streptococcus species
Sickle cell anemia patients Salmonella species are most common in patients with sickle cell disease.[2]

In children, the long bones are usually affected. In adults, the vertebrae and the pelvis are most commonly affected.

Acute osteomyelitis almost invariably occurs in children. When adults are affected, it may be because of compromised host resistance due to debilitation, intravenous drug abuse, infectious root-canaled teeth, or other disease or drugs (e.g., immunosuppressive therapy).

Osteomyelitis is a secondary complication in 1–3% of patients with pulmonary tuberculosis.[1] In this case, the bacteria, in general, spread to the bone through the circulatory system, first infecting the synovium (due to its higher oxygen concentration) before spreading to the adjacent bone.[1] In tubercular osteomyelitis, the long bones and vertebrae are the ones that tend to be affected.[1]

Pseudomonas aeruginosa is the most common organism seen in osteomyelitis, seeded from areas of contiguous infection. But Staphylococcus aureus The most common form of the disease in adults is caused by injury exposing the bone to local infection.

Bloodstream-sourced osteomyelitis is seen most frequently in children, and nearly 90% of cases are caused by Staphylococcus aureus. In infants, S. aureus, Group B streptococci (most common[3]) and Escherichia coli are commonly isolated; in children from one to 16 years of age, S. aureus, Streptococcus pyogenes, and Haemophilus influenzae are common. In some subpopulations, including intravenous drug users and splenectomized patients, Gram-negative bacteria, including enteric bacteria, are significant pathogens.[4]

[1], E. coli, and Serratia marcescens, are also common. Mixed infections are the rule rather than the exception.[4]

Systemic mycotic (fungal) infections may also cause osteomyelitis. The two most common are Blastomyces dermatitidis and Coccidioides immitis.

In osteomyelitis involving the vertebral bodies, about half the cases are due to S. aureus, and the other half are due to tuberculosis (spread hematogenously from the lungs). Tubercular osteomyelitis of the spine was so common before the initiation of effective antitubercular therapy, it acquired a special name, Pott's disease.

The Burkholderia cepacia complex has been implicated in vertebral osteomyelitis in intravenous drug users.[5]


In general, microorganisms may infect bone through one or more of three basic methods

The area usually affected when the infection is contracted through the bloodstream is the enzymes that lyse the bone. Pus spreads into the bone's blood vessels, impairing their flow, and areas of devitalized infected bone, known as sequestra, form the basis of a chronic infection.[1] Often, the body will try to create new bone around the area of necrosis. The resulting new bone is often called an involucrum.[1] On histologic examination, these areas of necrotic bone are the basis for distinguishing between acute osteomyelitis and chronic osteomyelitis. Osteomyelitis is an infective process that encompasses all of the bone (osseous) components, including the bone marrow. When it is chronic, it can lead to bone sclerosis and deformity.

Chronic osteomyelitis may be due to the presence of intracellular bacteria (inside bone cells).[7] Also, once intracellular, the bacteria are able to escape and invade other bone cells.[8] At this point, the bacteria may be resistant to some antibiotics.[9] These combined facts may explain the chronicity and difficult eradication of this disease, resulting in significant costs and disability, potentially leading to amputation. Intracellular existence of bacteria in osteomyelitis is likely an unrecognized contributing factor to its chronic form.

In infants, the infection can spread to a joint and cause arthritis. In children, large subperiosteal abscesses can form because the periosteum is loosely attached to the surface of the bone.[1]

Because of the particulars of their blood supply, the tibia, femur, humerus, vertebra, the maxilla, and the mandibular bodies are especially susceptible to osteomyelitis.[10] Abscesses of any bone, however, may be precipitated by trauma to the affected area. Many infections are caused by Staphylococcus aureus, a member of the normal flora found on the skin and mucous membranes. In patients with sickle cell disease, the most common causative agent is Salmonella, with a relative incidence more than twice that of S. aureus.[2]


Mycobacterium doricum osteomyelitis and soft tissue infection. Computed tomography scan of the right lower extremity of a 21-year-old patient, showing abscess formation adjacent to nonunion of a right femur fracture.

The diagnosis of osteomyelitis is complex and relies on a combination of clinical suspicion and indirect laboratory markers such as a high white blood cell count and fever, although confirmation of clinical and laboratory suspicion with imaging is usually necessary.[11]

Radiographs and CT are the initial method of diagnosis, but are not sensitive and only moderately specific for the diagnosis. They can show the cortical destruction of advanced osteomyelitis, but can miss nascent or indolent diagnoses.[11]

Confirmation is most often by MRI. The presence of edema, diagnosed as increased signal on T2 sequences, is sensitive, but not specific, as edema can occur in reaction to adjacent cellulitis. Confirmation of bony marrow and cortical destruction by viewing the T1 sequences significantly increases specificity. The administration of intravenous gadolinium based contrast enhances specificity further. In certain situations, such as severe Charcot arthropathy, diagnosis with MRI is still difficult.[11] Similarly, it is limited in distinguishing bone infarcts from osteomyelitis in sickle cell anemia.[12]

Nuclear medicine scans can be a helpful adjunct to MRI in patients who have metallic hardware that limits or prevents effective magnetic resonance. Generally a triple phase technetium 99 based scan will show increased uptake on all three phases. Gallium scans are 100% sensitive for osteomyelitis but not specific, and may be helpful in patients with metallic prostheses. Combined WBC imaging with marrow studies have 90% accuracy in diagnosing osteomyelitis.[13]

Diagnosis of osteomyelitis is often based on radiologic results showing a lytic center with a ring of sclerosis.[1] Culture of material taken from a bone biopsy is needed to identify the specific pathogen; alternative sampling methods such as needle puncture or surface swabs are easier to perform, but do not produce reliable results.[14]

Factors that may commonly complicate osteomyelitis are fractures of the bone, amyloidosis, endocarditis, or sepsis.[1]


Osteomyelitis often requires prolonged antibiotic therapy for weeks or months. A PICC line or central venous catheter can be placed for long-term intravenous medication administration. It may require surgical debridement in severe cases, or even amputation.

Initial first-line antibiotic choice is determined by the patient's history and regional differences in common infective organisms. A treatment lasting 42 days is practiced in a number of facilities.[15] Local and sustained availability of drugs have proven to be more effective in achieving prophylactic and therapeutic outcomes.[16] Open surgery is needed for chronic osteomyelitis, whereby the involucrum is opened and the sequestrum is removed or sometimes saucerization[17] can be done. Hyperbaric oxygen therapy has been shown to be a useful adjunct to the treatment of refractory osteomyelitis.[18][19]

Prior to the widespread availability and use of antibiotics, blow fly larvae were sometimes deliberately introduced to the wounds to feed on the infected material, effectively scouring them clean.[20][21] In 1875, American artist Thomas Eakins depicted a surgical procedure for osteomyelitis at Jefferson Medical College, in a famous oil painting titled The Gross Clinic.

Fossil record

Evidence for osteomyelitis found in the fossil record is studied by paleopathologists, specialists in ancient disease and injury. It has been reported in fossils of the large carnivorous dinosaur Allosaurus fragilis.[22]

See also

Media related to at Wikimedia Commons


  1. ^ Derived from Greek words osteon, meaning bone, myelo- meaning marrow, and -itis meaning inflammation


  1. ^ a b c d e f g h i j k Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; & Mitchell, Richard N. (2007). Robbins Basic Pathology (8th ed.). Saunders Elsevier. pp. 810–811 ISBN 978-1-4160-2973-1
  2. ^ a b Burnett, M.W.; J.W. Bass; B.A. Cook (1998-02-01). "Etiology of osteomyelitis complicating sickle cell disease.".  
  3. ^ Haggerty, Maureen (2002). "Streptococcal Infections".  
  4. ^ a b Carek, P.J.; L.M. Dickerson; J.L. Sack (2001-06-15). "Diagnosis and management of osteomyelitis".  
  5. ^ Weinstein, Lenny; Knowlton, Christin A.; Smith, Miriam A. (2007-12-16). "Cervical osteomyelitis caused by Burkholderia cepacia after rhinoplasty".  
  6. ^ a b Luqmani, Raashid; Robb, James; Daniel, Porter; Benjamin, Joseph (2013). Orthopaedics, Trauma and Rheumatology (second ed.). Mosby. p. 96.  
  7. ^ Ellington Microb Pathog 1999
  8. ^ Ellington JBJS Br 2003
  9. ^ Ellington J Ortho Res 2006
  10. ^ King MD, Randall W.; David Johnson, MD, FACEP (2006-07-13). "Osteomyelitis".  
  11. ^ a b c PMID 22981480 (PubMed)
  12. ^ PMID 26209118 (PubMed)
  13. ^ PMID 16264122 (PubMed)
  14. ^ Senneville E, Morant H, Descamps D, et al. (2009). "Needle puncture and transcutaneous bone biopsy cultures are inconsistent in patients with diabetes and suspected osteomyelitis of the foot". Clin Infect Dis 48 (7): 888–93.  
  15. ^ Putland M.D, Michael S., Hyperbaric Medicine, Capital Regional Medical Center, Tallahassee, Florida, personal inquiry June 2008.
  16. ^ Soundrapandian, C; Datta S; Sa B (2007). "Drug-eluting implants for osteomyelitis". Crit Rev Ther Drug Carrier Syst. 24 (6): 493–545.  
  17. ^ http://medical
  18. ^ Mader JT, Adams KR, Sutton TE (1987). "Infectious diseases: pathophysiology and mechanisms of hyperbaric oxygen". J. Hyperbaric Med 2 (3): 133–140. Retrieved 2008-05-16. 
  19. ^ Kawashima M, Tamura H, Nagayoshi I, Takao K, Yoshida K, Yamaguchi T (2004). "Hyperbaric oxygen therapy in orthopedic conditions". Undersea Hyperb Med 31 (1): 155–62.  
  20. ^ Baer M.D., William S. (1 July 1931). "The Treatment of Chronic Osteomyelitis with the Maggot (Larva of the Blow Fly)". Journal of Bone and Joint Surgery 13 (3): 438–475. Retrieved 2007-11-12. 
  21. ^ McKeever, Duncan Clark (June 2008). "The Classic: Maggots in Treatment of Osteomyelitis: A Simple Inexpensive Method".  
  22. ^ Molnar, R. E., 2001, Theropod paleopathology: a literature survey: In: Mesozoic Vertebrate Life, edited by Tanke, D. H., and Carpenter, K., Indiana University Press, p. 337-363.

Further reading

  • Mechanisms of Staphylococcus aureus invasion of cultured osteoblasts. Ellington JK, Reilly SS, Ramp WK, Smeltzer MS, Kellam JF, Hudson MC. Microb Pathog. 1999 Jun;26(6):317–23.
  • Intracellular Staphylococcus aureus. A mechanism for the indolence of osteomyelitis. Ellington JK, Harris M, Webb L, Smith B, Smith T, Tan K, Hudson M. J Bone Joint Surg Br. 2003 Aug;85(6):918–21.
  • Intracellular Staphylococcus aureus and antibiotic resistance: implications for treatment of staphylococcal osteomyelitis. Ellington JK, Harris M, Hudson MC, Vishin S, Webb LX, Sherertz R. J Orthop Res. 2006 Jan;24(1):87–93.

External links

  • Acosta, Chin;  
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