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Tefibazumab

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Tefibazumab

Tefibazumab?
Monoclonal antibody
Type Whole antibody
Source Humanized (from mouse)
Target Clumping factor A
Clinical data
Trade names Aurexis
Identifiers
CAS Registry Number  N
ATC code None
KEGG  Y
Chemical data
Formula C6548H10122N1730O2034S44
Molecular mass 147.590 kDa
 N   

Tefibazumab (named Aurexis but not approved) is a humanized monoclonal antibody for the treatment of severe infections with Staphylococcus aureus. Possible indications include the treatment of S. aureus in a phase 2a patients with cystic fibrosis[1] and of methicillin-resistant S. aureus.[2]

It was developed by Inhibitex.[3]

See also

  • MSCRAMM (microbial surface components recognizing adhesive matrix molecules)

References

  1. ^ Clinical trial number NCT00198289 at ClinicalTrials.gov
  2. ^ Pan; Lorenzotti, S.; Zoncada, A. (2008). "Registered and investigational drugs for the treatment of methicillin-resistant Staphylococcus aureus infection". Recent Patents on Anti-infective Drug Discovery 3 (1): 10–33.  
  3. ^ John JF (2006). "Drug evaluation: tefibazumab--a monoclonal antibody against staphylococcal infection". Curr. Opin. Mol. Ther. 8 (5): 455–60.  


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