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Clinical Trials


Clinical trials are conducted to allow safety and efficacy data to be collected for health interventions (e.g., drugs, diagnostics, devices, therapy protocols). These trials can take place only after satisfactory information has been gathered on the quality of the non-clinical safety, and Health Authority/Ethics Committee approval is granted in the country where the trial is taking place.

 
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A Pilot Study Using MacHine Learning and Domain Knowledge to Facil...

By: Santa Monica

Description: Comparative effectiveness reviews need to be updated frequently to maintain their relevance. Results of earlier screening efforts should be useful in reducing the screening of thousands of newer citations for articles relevant to efficacy/effectiveness and adverse effects (AEs).

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Cns Clinical Trials : Suicidality and Data Collection, Workshop Su...

By: National Academies Press US

Description: The Institute of Medicine’s Forum on Neuroscience and Nervous System Disorders planned and held a public workshop June 16, 2009, that brought together experts from industry, academia, government, and advocacy groups to discuss issues directly

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Privacy Issues in Biomedical and Clinical Research

By: National Clinical Guideline Centre Uk

Description: On November 1, 1997, the National Research Council’s Board on Biology brought together a group of scientists and other experts to discuss the policy issues raised by the ongoing revolution in genetic science. The primary reason for the worksh

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Research Training in the Biomedical, Behavioral, and Clinical Rese...

By: National Academies Press US

Description: The importance of research for the improvement of health and health care has been recognized both nationally and internationally for many decades. In the United States the most visible sign of this recognition is the strong and enduring suppo

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Plos Medicine : a New Vision for Clinical Trials in Africa, Volume...

By: Public Library of Science
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Plos Medicine : a Taxpayer-funded Clinical Trials Registry and Res...

By: Erick H. Turner
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Plos Medicine : is it Always Unethical to Use a Placebo in a Clini...

By: Andreas Stang
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Plos Medicine : Tackling Publication Bias in Clinical Trial Report...

By: Public Library of Science (Plos)
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Plos Medicine : Building Clinical Trials Capacity for Tuberculosis...

By: Neil Schluger
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Plos Medicine : Integration of Information Technologies in Clinica...

By: William Avilés
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Plos Medicine : Standardising Outcomes in Paediatric Clinical Tria...

By: Mike Clarke
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Plos Medicine : Incorporating Molecular Tools Into Early-stage Cli...

By: Robert J. Weil
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Plos Medicine : the Unintended Consequences of Clinical Trials Reg...

By: Alex D. McMahon
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Plos Medicine : Considering Usual Medical Care in Clinical Trial D...

By: Liza Dawson
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Plos Medicine : Open Clinical Trial Data for All a View from Regul...

By: Hans-georg Eichler
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Plos Medicine : the Imperative to Share Clinical Study Reports;Rec...

By: Peter Doshi
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Plos One : Towards National Surgical Surveillance in the Uk – a Pi...

By: John E. Mendelson

Description : Standarised surgical metrics can provide policy makers and commissioners with valuable summary data on surgical performance allowing for statistical process control of a complex intervention. This study has shown their collection is feasible albeit using FOI and the first to show a statistically significant volume-outcome relationship for surgery as a whole within hospitals. It adds weight to the argument that patients are safer in larger hospitals or those...

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Plos One : a Randomized Clinical Trial of an Inactivated Avian Inf...

By: Eliane Namie Miyaji

Description : This inactivated subunit influenza A (H7N7) vaccine was safe but poorly immunogenic in humans.

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Plos One : Registration Quality Assessment of Acupuncture Clinical...

By: Lamberto Manzoli

Description : The overall registration quality of ACTs is not high enough due to the serious lack of information on the specifics of acupuncture intervention. It is vital that a number of special items be set regarding acupuncture in order to develop a suitable system for the registration of ACTs.

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Plos One : Molecular and Clinical Studies in 138 Japanese Patients...

By: Miozzo Monica

Description : The results are grossly consistent with the previously reported data, although the frequency of epimutations is lower in the Japanese SRS patients than in the Western European SRS patients. Furthermore, the results provide useful information regarding placental hypoplasia in SRS, clinical phenotypes of the hypomethylated ARHI-DMR, and underlying causative factors for idiopathic SRS.

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